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Page 1
Repurposed Antiviral Drugs for Covid-19 - Interim WHO Solidarity Trial Results.
WHO Solidarity Trial Consortium; Pan H, Peto R, Henao-Restrepo AM, Preziosi MP, Sathiyamoorthy V, Abdool Karim Q, Alejandria MM, Hernández García C, Kieny MP, Malekzadeh R, Murthy S, Reddy KS, Roses Periago M, Abi Hanna P, Ader F, Al-Bader AM, Alhasawi A, Allum E, Alotaibi A, Alvarez-Moreno CA, Appadoo S, Asiri A, Aukrust P, Barratt-Due A, Bellani S, Branca M, Cappel-Porter HBC, Cerrato N, Chow TS, Como N, Eustace J, García PJ, Godbole S, Gotuzzo E, Griskevicius L, Hamra R, Hassan M, Hassany M, Hutton D, Irmansyah I, Jancoriene L, Kirwan J, Kumar S, Lennon P, Lopardo G, Lydon P, Magrini N, Maguire T, Manevska S, Manuel O, McGinty S, Medina MT, Mesa Rubio ML, Miranda-Montoya MC, Nel J, Nunes EP, Perola M, Portolés A, Rasmin MR, Raza A, Rees H, Reges PPS, Rogers CA, Salami K, Salvadori MI, Sinani N, Sterne JAC, Stevanovikj M, Tacconelli E, Tikkinen KAO, Trelle S, Zaid H, Røttingen JA, Swaminathan S. WHO Solidarity Trial Consortium, et al. N Engl J Med. 2021 Feb 11;384(6):497-511. doi: 10.1056/NEJMoa2023184. Epub 2020 Dec 2. N Engl J Med. 2021. PMID: 33264556 Free PMC article. Clinical Trial.
Death occurred in 301 of 2743 patients receiving remdesivir and in 303 of 2708 receiving its control (rate ratio, 0.95; 95% confidence interval [CI], 0.81 to 1.11; P = 0.50), in 104 of 947 patients receiving hydroxychloroquine and in 84 of 906 receiving its control (rate r …
Death occurred in 301 of 2743 patients receiving remdesivir and in 303 of 2708 receiving its control (rate ratio, 0.95; 95% confidence inter …
Muc4 loss mitigates epidermal growth factor receptor activity essential for PDAC tumorigenesis.
Bhatia R, Siddiqui JA, Ganguly K, Thompson CM, Cannon A, Aithal A, Perumal N, Maurya SK, Li X, Cox JL, Gurumurthy CB, Rachagani S, Jain M, Nasser MW, Batra SK, Kumar S. Bhatia R, et al. Oncogene. 2023 Mar;42(10):759-770. doi: 10.1038/s41388-022-02587-1. Epub 2023 Jan 9. Oncogene. 2023. PMID: 36624189 Free PMC article.
The Muc4 depletion in the autochthonous murine model carrying K-ras and p53 mutations (K-ras(G12D); TP53(R172H); Pdx-1cre, KPC) to generate the KPCM4(-/-) murine model showed a significant delay in the PanIN lesion formation with a significant reduction (p &l …
The Muc4 depletion in the autochthonous murine model carrying K-ras and p53 mutations (K-ras(G12D); TP53(R172H); Pdx-1cre, KPC …
Transfusion of Adult, but Not Neonatal, Platelets Promotes Monocyte Trafficking in Neonatal Mice.
Maurya P, Ture SK, Li C, Scheible KM, McGrath KE, Palis J, Morrell CN. Maurya P, et al. Arterioscler Thromb Vasc Biol. 2023 Jun;43(6):873-885. doi: 10.1161/ATVBAHA.122.318162. Epub 2023 Mar 23. Arterioscler Thromb Vasc Biol. 2023. PMID: 36951062 Free article.
Monocytes incubated with adult or neonatal mouse platelets had similar inflammatory (Ly6C(hi)) but different trafficking phenotypes, as defined by CCR2 and CCR5 mRNA and surface expression. Blocking P-sel (P-selectin) interactions with its PSGL-1 (P-sel glyco …
Monocytes incubated with adult or neonatal mouse platelets had similar inflammatory (Ly6C(hi)) but different trafficking phenotypes, as defi …
Nutrients enriched biochar production through Co-Pyrolysis of poultry litter with banana peduncle and phosphogypsum waste.
Vimal V, Karim AA, Kumar M, Ray A, Biswas K, Maurya S, Subudhi D, Dhal NK. Vimal V, et al. Chemosphere. 2022 Aug;300:134512. doi: 10.1016/j.chemosphere.2022.134512. Epub 2022 Apr 6. Chemosphere. 2022. PMID: 35398066
However, research is highly scarce on utilisation of waste materials for production of PL biochar enriched in P, potassium (K) and sulphur (S). In this context, present work investigated co-pyrolysis (700C, 10C/min, 1h residence time) of PL with banana peduncle (BP) …
However, research is highly scarce on utilisation of waste materials for production of PL biochar enriched in P, potassium (K) …
Decreased activity of Ca(++)-ATPase and Na(+)/K(+)-ATPase during aging in humans.
Maurya PK, Prakash S. Maurya PK, et al. Appl Biochem Biotechnol. 2013 May;170(1):131-7. doi: 10.1007/s12010-013-0172-8. Epub 2013 Mar 13. Appl Biochem Biotechnol. 2013. PMID: 23483411
The main purpose of this study is to understand the gender-based relationship between human aging and activities of two erythrocyte membranes bound enzymes, Ca(++)-ATPase and Na(+)/K(+)-ATPase. Ca(++)-ATPase and Na(+)/K(+)-ATPase activities were determined as per th …
The main purpose of this study is to understand the gender-based relationship between human aging and activities of two erythrocyte membrane …
A literature review of consent declines and consent withdrawals in randomized controlled trials conducted during the COVID-19 pandemic.
Gogtay NJ, Sheth HJ, Maurya MR, Belhekar MN, Thatte UM. Gogtay NJ, et al. J Postgrad Med. 2021 Jul-Sep;67(3):134-138. doi: 10.4103/jpgm.JPGM_77_21. J Postgrad Med. 2021. PMID: 34414930 Free PMC article. Review.

A significant difference was observed in consent declines between COVID-19 vs non-COVID-19 RCTs [4.3% vs 11.9%, p < 0.0001] and between COVID-19 RCTs vs two historical controls [(4.3% vs 8.6%, p < 0.0001) and (4.3% vs 21.1%, p < 0.0001), respectively

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A significant difference was observed in consent declines between COVID-19 vs non-COVID-19 RCTs [4.3% vs 11.9%, p < 0.0001] and be

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Targeting Artemisinin-Resistant Malaria by Repurposing the Anti-Hepatitis C Virus Drug Alisporivir.
Chaurasiya A, Kumari G, Garg S, Shoaib R, Anam Z, Joshi N, Kumari J, Singhal J, Singh N, Kaushik S, Kahlon AK, Dubey N, Maurya MK, Srivastava P, Marothia M, Joshi P, Gupta K, Saini S, Das G, Bhattacharjee S, Singh S, Ranganathan A. Chaurasiya A, et al. Antimicrob Agents Chemother. 2022 Dec 20;66(12):e0039222. doi: 10.1128/aac.00392-22. Epub 2022 Nov 14. Antimicrob Agents Chemother. 2022. PMID: 36374050 Free PMC article.
Here, we report the rational repurposing of the anti-hepatitis C virus drug, alisporivir, a nonimmunosuppressive analog of cyclosporin A, against artemisinin-resistant strains of P. falciparum. In silico docking studies and molecular dynamic simulation predicted strong int …
Here, we report the rational repurposing of the anti-hepatitis C virus drug, alisporivir, a nonimmunosuppressive analog of cyclosporin A, ag …
Comprehensive analysis of genetic factors predicting overall survival in Myelodysplastic syndromes.
Maurya N, Mohanty P, Dhangar S, Panchal P, Jijina F, Mathan SLP, Shanmukhaiah C, Madkaikar M, Vundinti BR. Maurya N, et al. Sci Rep. 2022 Apr 8;12(1):5925. doi: 10.1038/s41598-022-09864-9. Sci Rep. 2022. PMID: 35396491 Free PMC article.

The survival analysis revealed that the mutations in TP53, JAK2/3, KRAS, NRAS and ASXL1 were significantly (P < 0.05) associated with poor survival of the patients. The univariate cox and multivariate cox analysis of our study suggested that the age, marrow morphology,

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The survival analysis revealed that the mutations in TP53, JAK2/3, KRAS, NRAS and ASXL1 were significantly (P < 0.05) associated w

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Disruption of Ca2+i Homeostasis and Connexin 43 Hemichannel Function in the Right Ventricle Precedes Overt Arrhythmogenic Cardiomyopathy in Plakophilin-2-Deficient Mice.
Kim JC, Pérez-Hernández M, Alvarado FJ, Maurya SR, Montnach J, Yin Y, Zhang M, Lin X, Vasquez C, Heguy A, Liang FX, Woo SH, Morley GE, Rothenberg E, Lundby A, Valdivia HH, Cerrone M, Delmar M. Kim JC, et al. Circulation. 2019 Sep 17;140(12):1015-1030. doi: 10.1161/CIRCULATIONAHA.119.039710. Epub 2019 Jul 18. Circulation. 2019. PMID: 31315456 Free PMC article.
39 results